The phrase "tied in knots" can often refer to feeling anxious, stressed, or simply overwhelmed. Some antonyms for this phrase could include feeling calm, relaxed, or at ease. When you are tied in knots, you may feel trapped or stuck in a situation, whereas when you are calm and relaxed, you may feel a sense of clarity and freedom. Other antonyms for "tied in knots" could include feeling organized, focused, or composed. Ultimately, there are many different words that can help to convey the opposite of feeling tied in knots, and these words may be useful in helping you to calm down and regain your composure.