The phrase "tied in with" implies a connection or association between two or more things. Some antonyms or opposite phrases include "unrelated to," "disconnected from," or "dissociated with." These phrases suggest a lack of connection, independence, or detachment. Other antonyms could be "independent of," "separate from," or "distinct from," which highlight the autonomy or separation of each entity. While "tied in with" may connote a strong relationship or dependency, opposites like "uncomplicated by" or "unaffected by" imply a lack of reliance or influence. Ultimately, the antonyms of "tied in with" signal varying degrees of separation, independence, or detachment between entities.