The word "un-fortunateness" refers to bad luck or an unfortunate event. Some synonyms for this word include misfortune, adversity, calamity, setback, and tragedy. Misfortune refers to an unfortunate event or situation that causes difficulty or suffering. Adversity is a difficult or challenging situation that one must overcome. Calamity denotes a sudden disaster or a great misfortune. Setback refers to a delay or a problem that slows down progress or achievement. Tragedy refers to a disastrous event that causes great suffering or loss. These synonyms can all be used in place of "un-fortunateness" to describe negative situations or events that one may encounter in life.