The antonyms for the word "up individual" are mostly related to characteristics such as sluggishness or laziness. The opposite of an up individual could be someone who is down, lethargic, tired or slothful. A person who lacks drive or motivation, or is inactive, apathetic, or weak, could also be considered an antonym of an up individual. Individuals who lack enthusiasm or interest in personal development, who are unmotivated or uninspired, could be considered the opposite of those who are "up." People who are dispirited, lack energy or vitality, or who are easily discouraged, would also not be described as being "up.