Vacuousness refers to a state of emptiness or lack of substance. Synonyms for this word could include hollowness, emptiness, shallowness, superficiality, insubstantiality, airy-fairy, and vaporosity. Another word that could be used is vacuity, which refers to an empty space or the lack of content or substance. Other related words that could be used as synonyms include inanity, blankness, nothingness, and barrenness. These synonyms all refer to a lack of depth or substance and can be used interchangeably with vacuousness depending on the context in which they are used.