Vaginal agenesis, also known as Mayer-Rokitansky-Küster-Hauser syndrome, is a congenital disorder where a female is born without a vagina or with an underdeveloped one. There are various synonyms used to describe this condition, such as vaginal aplasia, vaginal hypoplasia, vaginal dysgenesis, and congenital absence of the vagina. Although the condition is rare, it can lead to significant psychological distress and sexual dysfunction for affected individuals. Treatment options include vaginal dilation, surgery to create a neovagina, or the use of a vaginal mold or stent. Early intervention and support can help individuals with vaginal agenesis live healthy and fulfilling lives.