Afibrinogenemia is a rare genetic disorder that causes deficient levels of fibrinogen in the blood, resulting in an inability to form blood clots. There are few synonyms for this condition, but they include hypofibrinogenemia, congenital fibrinogen deficiency, and dysfibrinogenemia. While these terms are not interchangeable, they are often used to refer to various forms of fibrinogen disorders. Individuals with afibrinogenemia require lifelong management and treatment, which may include replacement therapy with fibrinogen or plasma. Symptoms may include bruising easily, prolonged bleeding, and excessive menstrual bleeding. Early diagnosis and treatment are crucial to prevent life-threatening bleeding episodes.