The antonyms for the word "are refreshed" are words that describe a lack of energy, vitality or excitement. Some of these antonyms include "are lethargic," "are tired," "are drained," "are exhausted," "are fatigued," "are depleted," "are uninspired," "are listless," and "are weary." These words suggest a state of weariness, dullness, and apathy. On the other hand, their counterparts, "are refreshed," "are energized," and "are invigorated," imply that someone is alert, lively, and full of vigor. Special attention should be given to the state of being refreshed, as it suggests renewed vigor and enthusiasm that help one tackle the challenges of daily life.