"Be significant of" is a phrase that implies that something is indicative or symbolic of something else. There are a variety of synonyms for this phrase including, "suggest," "hint at," "point to," "imply," "denote," "signify," "represent," or "convey." Each of these words suggest that an action or event is a sign or an indication of something else. For example, a person's sudden disappearance may suggest foul play or a hint of danger. Alternatively, a big smile might convey happiness or signify a victory. Ultimately, the phrase "be significant of" is a powerful tool in expressing connections between events, actions, and implications.