Bone-weary typically refers to a state of extreme exhaustion or weariness. Antonyms for this word would include energy, vitality, and enthusiasm. Someone who is full of energy would be far from bone-weary, and might be described as lively or even exuberant. Equally, someone who is filled with vitality would be considered healthy, lively, and full of life, while someone who is enthusiastic would display a genuine interest in and passion for life. All of these antonyms describe the opposite of bone-weary, and they indicate a state of vibrancy, energy, and vitality that is full of life and excitement.