The phrase "by and of itself" is often used to indicate that something has certain inherent qualities or characteristics. Synonyms for this phrase include "intrinsically," "naturally," "essentially," and "fundamentally." These words suggest that something has its own unique properties independent of any external factors. Other potential synonyms for "by and of itself" might include "inherently," "inherently," "intrinsic," or "inherently." Regardless of which synonym you use, the underlying meaning is the same: that something has an essential quality that cannot be explained or altered by external factors. Using these synonyms can help you convey a clearer and more precise message in your writing.