Christmas disease, also known as Hemophilia B, is a rare bleeding disorder that affects one in 25,000 males. This genetic disorder is caused by a lack of clotting factor IX, which is essential for blood coagulation. While the term "Christmas disease" is commonly used, there are other synonyms for the same condition. One of the most commonly used terms is Hemophilia B, identified by the deficiency of clotting factor IX. Christmas disease is also referred to as thrombophilia, due to the increased risk of blood clots it causes, or bleeders' disease. While these names are different, they all point towards the same rare medical condition that can lead to severe bleeding.