The phrase "come out against" can be replaced with several other synonyms in a given context. Some of the common options include object, protest, oppose, denounce, condemn, reject, or criticize. These synonyms suggest that a person or a group is expressing disagreement, disapproval, or a contrary opinion against something they believe is wrong or unethical. For example, one may say, "The company's decision to lay off employees caused public outcry, with many politicians and labor leaders coming out against the move." Here, "coming out against" could be replaced with "protesting," "opposing," or "denouncing." Overall, using synonyms helps to add variety to one's speech or writing while effectively conveying the intended message or stance.