De-spiteful, meaning not cruel or vindictive, has several antonyms, or opposites. One antonym is spiteful or vindictive, meaning having or showing a desire to harm, hurt, or annoy others. Other antonyms include malevolent, malicious, hateful, vengeful, revengeful, and mean-spirited. These words all describe someone who is inclined to cause harm or trouble to others for little or no reason. In contrast, de-spiteful describes someone who is kind, forgiving, and understanding, and who is not motivated by a desire to hurt others. When we are de-spiteful, we strive to create a positive and supportive environment for ourselves and others.