De-squamate is a medical term used to describe the process of shedding scaly skin. Opposite or antonyms of de-squamate are terms that describe the opposite process of scaling or flaking. Some antonyms of de-squamate include "exfoliate," "peel," "shed," "slough," "flake," or "flay." These words describe the natural process of skin regeneration, where dead skin cells are removed from the top layer of the skin. Exfoliating the skin regularly using gentle methods can help unclog pores, prevent breakouts, and reveal smoother, healthier-looking skin. While de-squamate occurs naturally, exfoliation using scrubs, masks, or acids is an effective way to keep your skin looking and feeling its best.