The phrase "does with" can be replaced by a variety of synonyms depending on the context. For example, in terms of coping or handling something, alternatives could include "deals with", "manages", or "confronts". In discussing someone's actions or behavior, other options might include "behaves", "conducts", or "acts". In the realm of accomplishing a task or completing something, synonyms for "does with" might include "executes", "performs", or "fulfills". Overall, the available synonyms for "does with" can vary widely depending on the situation, but they all ultimately relate to the idea of taking action and making progress in some way.