Doped up is a slang term that means being under the influence of drugs. Antonyms to this word might include sober, clear-headed, alert, attentive, and focused. Sober is the opposite of being intoxicated and means free from drug influence. Clear-headed suggests a person is thinking in a rational way, without any impairment from drugs. Alert is used when someone is watchful and fully awake, making quick assessments of situations, while attentive implies paying careful attention to details. Finally, focused is when someone is highly concentrated, with profound mental and emotional engagement, without any distractions or disturbances from drugs. Together, these antonyms provide a range of alternatives for doped up to describe a person's state of mental, physical, and emotional awareness without any influence from drugs.