The term "hypersensitised" signifies an excessive sensitivity or susceptibility towards something. Its antonyms could be acclimated, immune, desensitised, toughened, resilient, unresponsive, thick-skinned, callous, indifferent, or numb. Acclimated means that a person has become accustomed to certain conditions, which does not irritate or discomfort them anymore. Someone who is immune has no vulnerable response to particular allergens, viruses or bacteria. The word desensitised implies that a person has been gradually accustomed to something, or their sensitivity has decreased over time. They have become toughened or strengthened against that thing, making it less distressing. Thus, in contrast, the terms unresponsive or indifferent mean complete absence of sensitivity, emotion, or concern to a particular stimulus.