The antonyms for the term little game are serious, significant, and real. While the term little game refers to something that is small or insignificant, the antonyms suggest something that is important, weighty, and substantial. A serious game is one that requires concentration and is not meant for mere entertainment. A significant game is important in terms of its impact, outcome, or significance. A real game refers to a game that is not imaginary, but one that involves actual events or consequences. In contrast to little game, which can refer to something casual, insincere, or trivial, these antonyms suggest something serious, meaningful, and consequential.