The word "more empty-handed" suggests having even less than nothing. In the world of antonyms, there are several options that could fit the bill of having something instead of nothing. Some antonyms include having something, filled, abundant, rich, or full. These words suggest a sense of fullness or completeness, which is the opposite of empty-handed. For instance, saying "more rich-handed" or "more filled-handed" is the opposite of the phrase. No matter what antonym is used, the end result is that a person has something, which is entirely different from having nothing at all.