The phrase "most clean-handed" implies a person who is innocent or blameless, with no involvement in wrongdoings. Its antonyms are words that describe the opposite, such as "guilty," "culpable," "complicit," or "corrupt." These words suggest a person who has done something wrong or is involved in illicit activities. Additionally, words like "dirty-handed," "implicated," or "tainted" can be used to contrast with "most clean-handed." It is essential to understand the tone and context of the sentence to choose the right antonym. By using the appropriate antonym, one can create a balanced and well-rounded expression.