Most depressant refers to something that causes a decrease in activity or mood. The antonyms for most depressant would be words that describe things that increase activity or lift one's mood. Some examples of antonyms for most depressant include stimulant, invigorating, energizing, uplifting, refreshing, inspiring, and exhilarating. These words are often used to describe things like exercise, music, laughter, positivity, and motivation, which have the ability to increase energy and improve one's outlook on life. By focusing on antonyms for most depressant, individuals can work to combat feelings of sadness or lethargy and regain a sense of vitality and positivity.