The word "disquisitive" means fond of discussion or argument. Its antonyms would, therefore, mean the opposite - i.e., terms that are linked with disinterest, indifference, or a lack of curiosity. Some possible antonyms for "most disquisitive" include uninterested, apathetic, withdrawn, disengaged, detached, uncurious, obtuse, and incurious. Of course, the opposite of "most disquisitive" would depend on the context in which it's used. For instance, in some cases, antonyms like complacent, satisfied, or content might be fitting, while in other cases, antonyms like aloof, distant, or cold might be more appropriate. The choice of an antonym will depend on the intended meaning and context of the word being negated.