The term "most opposed" can be defined as the strongest or most intense form of disagreement or resistance towards something. There are various synonyms that can be used, depending on the context. Some of the similar words that can be substituted for "most opposed" include "strongly against," "adamantly opposed," "vehemently resist," "firmly reject," "antagonistically disapprove," "avidly protest," and "fiercely object." These words describe a high level of opposition and can be useful in expressing strong emotions or viewpoints. Choosing the appropriate synonym will help convey the intended meaning accurately and effectively.