The antonym for the term "most screwed" would be "most successful" or "most fortunate." These terms imply a sense of achievement and triumph in one's endeavors, rather than a sense of despair or hopelessness. Other antonyms that can be used for "most screwed" include "most thriving," "most prosperous," "most thriving," "most lucky," or "most opportune." These words all convey a positive and optimistic sentiment, and are often used to describe people, situations, or events that are doing well and thriving. By using these antonyms, you can provide a more positive and encouraging outlook on any situation.