Most shifted is a term that signifies a significant change or movement in a particular direction. Its antonym would be least shifted, which refers to a situation where there is very little or no change. It may also mean a condition where something has remained the same, unmoved or unshifted. Other antonyms for most shifted could be stationary, unchanging, immobile, static, and fixed. These words describe things that have maintained their position, and there has been no movement or shift since. In a sense, least shifted indicates stability, which is the opposite of change, indicating a shift or movement.