The phrase "most sure enough" indicates a high degree of certainty. Antonyms for this phrase may include words such as doubtful, uncertain, unsure, or skeptical. These words convey the opposite of confidence, and may be used to express a lack of trust or faith in a particular statement or situation. Other antonyms may include words like hesitant, tentative, or apprehensive, which suggest a level of caution or hesitation. In some cases, the antonym for "most sure enough" could simply be less certain, indicating a lower level of confidence or conviction.