Most sure-enough means being completely certain about something. Some of the antonyms for most sure-enough include doubt, unsure, uncertain, dubious or skeptical. When we are uncertain or doubtful, we do not have full confidence in something. We feel unsure, hesitant or even skeptical about it. At times, we may be skeptical about something despite it being true or factual. Uncertainty leaves room for error, whereas being most sure-enough is the exact opposite. Therefore, we should strive to be most sure-enough in our decision-making to avoid mistakes or regret.