The antonyms for the term "most tired-out" could be words or phrases such as energetic, revitalized, rejuvenated, refreshed, lively, active, revitalized, reenergized, enthusiastic, invigorated, and animated. These opposites suggest a state of vigor, alertness, and vitality, which is quite the opposite of feeling worn out or exhausted. Each antonym has its unique nuance, but all describe a feeling of being full of energy and life. Rather than feeling tired-out, these words imply that one is eager and ready to take on the day's challenges. Ultimately, these opposite words of "most tired-out" embody a state of liveliness, which is as desirable as being well-rested.