The phrase "most tissued" refers to something that is covered in a lot of tissue or has a lot of tissue attached to it. Some synonyms for this might include "most padded," "most cushioned," "most swathed in tissue," or "most wrapped." Depending on the context, other options could include "most laminated," "most quilted," "most insulated," or "most cocooned." All of these terms suggest a high degree of protection or a surface that is intentionally made more comfortable or soft through the addition of extra material. Regardless of the specific synonym chosen, the overall impression is one of added layers or bulk.