The antonyms for the word "most tiredout" would be "energetic," "refreshed," "lively," "animated," "enerized," "rested," "rejuvenated," and "revitalized." These words depict the opposite state of being exhausted, drained, and lethargic. After a good sleep, exercise, or vacation, one feels revived, lively, and full of energy, which is the exact opposite of feeling weary, weary, and sluggish. So, if you are feeling most tiredout after a long day at work or a hectic schedule, take a short break and rejuvenate yourself with some relaxation techniques, meditation or yoga to feel refreshed, energized and rejuvenated.