Most tuned in is an adjective phrase that expresses a high level of knowledge, awareness or interest. The antonyms for this phrase include disinterested, uninformed, oblivious, ignorant, and apathetic. Disinterested suggests a complete lack of interest, while uninformed suggests a lack of factual knowledge. Oblivious implies a lack of awareness, while ignorant suggests a lack of understanding or knowledge. Finally, apathetic suggests an absence of emotion or enthusiasm. When used in context, these antonyms can help to provide a clear contrast to the meaning of "most tuned in" and help to convey a specific message or concept.