Antonyms for the word "most tuned-in" are those that are characterized by being out of touch or unaware. Some of the possible antonyms to this term include ignorant, uninformed, disconnected, unenlightened, inattentive, oblivious, and disinterested. These antonyms describe people who lack knowledge, awareness, attentiveness, and sensitivity to issues and events in their environment. They are not focused on what is happening around them and are often disconnected from the people and world around them. The antonyms of "most tuned-in" create a stark contrast to individuals who are well-informed, observant, engaged, and aware of the latest developments, trends, and issues in different aspects of life.