Nervous exhaustion refers to a feeling of extreme tiredness or fatigue caused by emotional stress, anxiety or depression. There are several synonyms that can be used in place of nervous exhaustion, including burnout, fatigue, weariness, listlessness, lethargy, malaise, and fatigue syndrome. Burnout is a term used to describe the feeling of being emotionally, mentally and physically drained due to persistent stress and overwork. Similarly, fatigue, weariness, and lethargy describe feelings of extreme tiredness and lack of energy. Malaise generally refers to a feeling of general discomfort, unease, or illness, while fatigue syndrome is a medical condition characterized by an ongoing sense of fatigue that is not relieved by rest.