Perisynaptic refers to the area surrounding or adjacent to a synapse, the gap between two neurons through which nerve impulses are transmitted. Synonyms for perisynaptic include peri-synaptic, juxtacrine, or extrasynaptic. Peri-synaptic refers to the area immediately surrounding a synapse, whereas juxtacrine pertains to a specific type of cell-to-cell communication that occurs in close proximity. Extrasynaptic describes any location outside of the synapse, such as the perisynaptic space. Other related terms include synaptic cleft, synaptic vesicles, and synaptic transmission. Understanding these synonyms and terms can aid in the understanding of the complex processes that occur at the synapse, which play a critical role in the functioning of the nervous system.