The word "pick upon" can be antonymized by several terms including "ignore," "neglect," and "overlook." To ignore means to disregard or pay no attention to something or someone. Neglect on the other hand means to fail to take care of or acknowledge something. Overlook implies missing or failing to notice something or someone, often unintentionally. These terms, unlike pick upon, connote a sense of nonchalance or indifference, indicating that the subject is not worth wasting any energy on. By considering these antonyms, one can better understand the nuances and contrasts of the term pick upon and its various connotations.