Pre-serve is a word that means to maintain something in its original condition or to protect it from harm or decay. The antonyms for pre-serve are words that describe actions that bring about the opposite of preservation. Such words include destroy, harm, damage, spoil, and deteriorate. Destroy means to ruin or annihilate something completely. Damage means to inflict harm, weaken, or impair something. Spoil means to impair the quality or value of something, or to ruin or destroy it entirely. Deteriorate means to become worse in quality, value or condition. In essence, antonyms of pre-serve are words that indicate the opposite of the efforts we make to keep things intact and in their pristine condition.