The antonyms for the word "re-invigorated" are words that describe a loss of energy and vitality. Some of the antonyms include: drained, exhausted, fatigued, worn out, depleted, sluggish, and lethargic. These words describe a state of physical, emotional or mental weariness that can be caused by overwork, stress, illness, or lack of sleep. When one is drained or exhausted, they may lack motivation, enthusiasm, and creativity. It is important to recognize the antonyms of reinvigoration in order to avoid burnout, take time to recharge and replenish the energy reserves. By balancing rest and activity, and nourishing the body and mind, we can increase our stamina, resilience, and vitality.