Re-invigorating means to impart new energy or vitality to something. Some antonyms of re-invigorating include draining, exhausting, tiring, enervating, weakening, dulling, and sapping. Draining refers to the act of using up an individual's energy or resources, leaving them feeling depleted. Exhausting means to use up a person's energy or resources to the point of fatigue, causing extreme tiredness. Tiring is the act of making someone feel physically or mentally exhausted. Enervating results in causing someone to feel weak, lacking focus or energy. Weakening means to reduce the strength, power or influence of something. Dulling refers to making someone or something less sharp or vibrant, while sapping means to gradually weaken or destroy something.