The antonyms for the word "setting ease" would be anything that causes discomfort, difficulty, or stress. This could include situations like being in a high-pressure job, dealing with difficult people, or facing unexpected challenges. Factors like fear, anxiety, and uncertainty can all contribute to feelings of unease or discomfort. Opposites of "setting ease" might include phrases like "adding stress," "creating tension," or "causing discomfort." Whatever the situation, finding ways to cope with stress and manage feelings of unease can help you maintain a sense of balance, happiness, and well-being in your life.