Antonyms for the word soothingness can be words like disturbing, irritating, unsettling, uncomfortable, agitating, or upsetting. The opposite of something that is soothing is something that causes discomfort, annoyance, or even emotional distress. For example, a loud noise could be a disturbing sound that does not calm our nerves, and it can be an interrupting factor when we are trying to relax or find comfort. In contrast, a soft melody, a gentle breeze, or a warm bath can have a soothing effect that leads to a pleasant feeling of relaxation and calmness.