Soothingnesses is a plural noun that refers to the state or quality of being calming, comforting or relaxing. Since it is a relatively rare term, there are not many well-established antonyms for this word. However, one possible antonym could be 'irritation' which signifies a state of frustration, annoyance, or agitation. Another antonym could be 'disturbance' which refers to a state of disruption, disturbance, or disquiet. Other antonyms might include turbulence, distress, unrest, or anxiety, all of which convey a sense of unease or discomfort, contrary to soothingnesses.