The phrase "takes off as" can be replaced with several other synonyms, depending on the context of the sentence. For example, it could be substituted with "skyrockets," "surges," "bolts," "zooms," or "jumps." These words all imply sudden and significant growth or momentum. In the context of a business or career, "takes off as" can also be replaced with "launches," "starts," or "commences," to indicate the beginning of a successful venture. However, it is important to consider the specific connotation and meaning of the substitute words to ensure they accurately convey the intended message.