"Whats upped" is a slang term that is commonly used to ask someone how they are doing or what is new in their life. It is often used in casual conversations between friends and acquaintances. There are a number of synonyms that can be used interchangeably with "whats upped", such as "how's it going?", "what's new?", "what's happening?", "what's the latest?", and "what's popping?". All of these phrases serve as a way to initiate conversation and express interest in the other person's life. Whether you use "whats upped" or one of its synonyms, the goal is to connect with the other person and catch up on each other's lives.