The antonym for "acting with regard to" is "ignoring" or "neglecting." When someone is not acting with regard to a particular situation, it means they are not paying attention to the details or considering the consequences of their actions. Ignoring important aspects of a situation can lead to negative outcomes and cause unnecessary harm. It is important to act with regard to our surroundings and make informed decisions that take into account all variables. By neglecting to do so, we risk making mistakes that could have easily been avoided. In conclusion, acting with regard to a situation is important for personal and professional success, and ignoring it can lead to catastrophic consequences.