Antonyms for the phrase "amuse oneself with" could be "bore oneself with," "disgust oneself with," or "frustrate oneself with." These phrases suggest the opposite of finding enjoyment or pleasure in an activity, and instead imply the negative emotions of boredom, disgust, or frustration. Amusement is often associated with light-hearted activities, such as playing games or reading books, while boredom and frustration can come from tedious or unenjoyable tasks. Using antonyms in this context can help to describe a situation where someone is not finding joy in a particular activity, and may be feeling negative emotions instead.