Antonyms for the word "get-up-and-go" are words that describe a lack of energy or enthusiasm. These include terms like lethargy, apathy, and sluggishness. Someone who lacks "get-up-and-go" may be described as lazy or unmotivated, without the drive to pursue their goals or take action towards improving their situation. In contrast, someone with a high level of "get-up-and-go" may be said to be dynamic, proactive, and full of vigor. Antonyms like "listlessness" and "dejection" describe a sense of resignation or hopelessness that can sap the vitality from even the most energetic person. Overall, having "get-up-and-go" is an essential quality for achieving success and fulfillment in life.