The phrase "hand in glove" represents a close and harmonious relationship between two entities. However, there are several antonyms that convey a completely opposite meaning. Some of the antonyms for this phrase are antagonistic, incompatible, adverse, aloof, distant, inharmonious, and detached. These antonyms signify a lack of understanding and cooperation between two parties. For example, if two individuals or organizations have an antagonistic relationship, they are usually in conflict with each other. In contrast, if two entities have a harmonious relationship, they work closely together, complement each other and achieve excellent outcomes. Therefore, using the appropriate word depending upon the situation can help in communicating the message effectively.