The term "palsy-walsy" is used to describe a friendship or relationship that is overly familiar, affectionate, or even insincere. When looking for antonyms to this term, one could focus on words that suggest distance or lack of familiarity. Some possible antonyms include aloof, detached, distant, reserved, formal, guarded, remote, cool, disinterested, and distant. These words are often used when referring to relationships that are professional, platonic, or simply lack emotional intimacy. By exploring the antonyms to "palsy-walsy," one can understand the range of relationships that exist and the importance of establishing clear boundaries in all interactions.