The opposite of "more copacetic" could be "less satisfactory" or "worse off." While copacetic means perfect, satisfactory, or harmonious, its antonyms portray a sense of dissatisfaction or discontent. "Less copacetic" could imply a reduction in quality or a decrease in one's happiness. Alternatively, "more problematic" or "more challenging" could be considered antonyms, suggesting difficulties instead of smoothness. In any case, the opposite of "more copacetic" will depend on the situation in which it is used, whether it pertains to a relationship, work, or personal life.